Erin Kaiser
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Induced pluripotent stem cell-derived neural stem cells (iNSCs) are a multimodal stroke therapeutic that possess neuroprotective, regenerative, and cell replacement capabilities post-ischemia. However, long-term engraftment and efficacy of iNSCs is limited by the cytotoxic microenvironment post-stroke. Tanshinone IIA (Tan IIA) is a therapeutic that demonstrates anti-inflammatory and antioxidative effects in rodent ischemic stroke models and…
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Dynamic changes in the oral microbiome have gained attention due to their potential diagnostic role in neurological diseases such as Alzheimer’s disease and Parkinson’s disease. Traumatic brain injury (TBI) is a leading cause of death and disability in the United States, but no studies have examined the changes in oral microbiome during the acute stage…
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Functional magnetic resonance imaging (fMRI) has significant potential to evaluate changes in brain network activity after traumatic brain injury (TBI) and enable early prognosis of potential functional (e.g., motor, cognitive, behavior) deficits. In this study, resting-state and task-based fMRI (rs- and tb-fMRI) were utilized to examine network changes in a pediatric porcine TBI model that…
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Acute magnetic resonance imaging helps predict functional recovery at chronic timepoints post-stroke
Magnetic resonance imaging (MRI) is a clinically relevant, real-time imaging modality that is frequently utilized to assess stroke type and severity. However, specific MRI biomarkers that can be used to predict long-term functional recovery are still a critical need. Consequently, the present study sought to examine the prognostic value of commonly utilized MRI parameters to…
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Harnessing the maximum diagnostic potential of magnetic resonance imaging (MRI) by including stroke lesion location in relation to specific structures that are associated with particular functions will likely increase the potential to predict functional deficit type, severity, and recovery in stroke patients. This exploratory study identified damaged brain structures including the insular cortex, somatosensory cortices,…
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Histopathological analysis of cellular changes in the stroked brain provides critical information pertaining to inflammation, cell death, glial scarring, and other dynamic injury and recovery responses. However, commonly used manual approaches are hindered by limitations in speed, accuracy, bias, and the breadth of morphological information that can be obtained. Here, a semi-automated high-content imaging (HCI)…
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The objective of this study was to characterize brain anatomy and assess spatiotemporal gait parameters in two commonly utilized research pig breeds, Yucatan and Landrace, pre- and post-stroke using magnetic resonance imaging (MRI) and gait analysis. This study demonstrated Yucatan and Landrace pigs exhibit differences in gross brain anatomy and gait patterns pre-stroke. However, stroke…
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Alcohol is one of the most commonly abused intoxicants with 1 in 6 adults at risk for alcohol use disorder (AUD). As such, rodent AUD models are widely studied however, inherent anatomical and physiological differences between rodents and humans pose a number of limitations in studying the complex nature of human AUD. Comparatively, this review…
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The findings of this proof of concept study strongly suggest that administration of Tanshinone IIA loaded nanoparticles (Tan IIA-NP) in the acute phase post-stroke mitigates neural injury likely through limiting free radical formation, thus leading to less severe gait deficits in a translational pig ischemic stroke model. With stroke as one of the leading causes…
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Recently, it has been demonstrated that neurological diseases and associated pathologies correlate with changes in the gut microbiota. However, changes in the microbial community in stroke have not been well characterized. This study investigated the changes in the gut microbiota composition and diversity using a pig stroke model. These findings provide a basis for characterizing…
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