Erin Kaiser
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It’s been almost a quarter century since the first drug was approved for stroke. But what’s even more striking is that only a single drug remains approved today. In a publication appearing this month in the journal Translational Stroke Research, the TNRR Laboratory and Aruna Bio, funded by the National Institutes of Health, present brain-imaging data for…
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Magnetic resonance imaging (MRI) is a clinically relevant non-invasive imaging tool commonly utilized to assess stroke progression in real time. This study investigated the utility of MRI as a predictive measure of clinical and functional outcomes when a stroke intervention is withheld or provided, in order to identify biomarkers for stroke functional outcome under these…
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The high morbidity and mortality rate of ischemic stroke in humans has led to the development of numerous animal models that replicate human stroke to further understand the underlying pathophysiology and to explore potential therapeutic interventions. Although promising therapeutics have been identified using these animal models, with most undergoing significant testing in rodent models, the…
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Dr. Franklin West received the Young Alumni Achiever award at the 65th annual University of Georgia College of Agricultural and Environmental Sciences Alumni Association Awards for his outstanding achievements.
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See our publication “Traumatic Brain Injury Results in Dynamic Brain Structure Changes Leading to Acute and Chronic Motor Function Deficits in a Pediatric Piglet Model” in the Journal of Neurotrauma.
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Traumatic brain injury (TBI) is a leading cause of death and disability in children. Pediatric TBI patients often suffer from crippling cognitive, emotional, and motor function deficits that have negative lifelong effects. The objective of this study was to longitudinally assess TBI pathophysiology using multi-parametric magnetic resonance imaging (MRI), gait analysis, and histological approaches in…
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The Translational Neural Repair and Regeneration Laboratory announces the publication of a novel study in the Journal of Neurotrauma in which controlled cortical impact led to cognitive and motor function deficits that correspond to cellular pathology in a piglet traumatic brain injury model.
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Traumatic brain injury (TBI) incidence has led to increased interest in utilizing large animal models to study pathophysiologic and functional changes after injury in hopes of identifying novel therapeutic targets. In the present study, a controlled cortical impact (CCI) piglet TBI model was utilized to evaluate cognitive, motor, and histopathologic outcomes.
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Dr. Franklin West and Dr. Qun Zhao discuss on Athens News Matters how pigs may play a critical role Alzheimer’s, Parkinson’s Disease, and chronic traumatic encephalopathy (CTE) research.
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Resting state functional MRI (fMRI) is an imaging method normally reserved for humans in order to analyze changes in brain activity. However, the Translational Neural Repair and Regeneration Laboratory has discovered that pig brains may be even better platforms than previously thought for the study of human neurological conditions. See our publication in Brain Connectivity
Posted in: Publications