Alcohol is one of the most commonly abused intoxicants with 1 in 6 adults at risk for alcohol use disorder (AUD). As such, rodent AUD models are widely studied however, inherent anatomical and physiological differences between rodents and humans pose a number of limitations in studying the complex nature of human AUD. Comparatively, this review describes how pigs and humans share anatomical similarities in the two major target organs of alcohol- the brain and liver. A porcine model of AUD possesses great translational potential that can significantly advance our current understanding of the complex development and continuance of AUD in humans. Read more of this paper at PubMed®.
