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Semi-automated analyses reveal regionally specific morphological alterations of immune and neural cells post-stroke

Histopathological analysis of cellular changes in the stroked brain provides critical information pertaining to inflammation, cell death, glial scarring, and other dynamic injury and recovery responses. However, commonly used manual approaches are hindered by limitations in speed, accuracy, bias, and the breadth of morphological information that can be obtained. Here,…
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Encapsulated Tanshinone IIA leads to reduced tissue injury and functional deficits post-stroke

For the first time, this study highlights the therapeutic efficacy of Tanshinone-IIA when encapsulated into nanoparticles. Specifically, Tanshinone IIA loaded nanoparticles demonstrate antioxidative capabilities in neural stem cell cultures; reduce lesion volume, midline shift, and white matter damage post-stroke; and improve spatiotemporal and kinetic gait parameters.
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Adolescent pigs exhibit binge drinking and motor deficits

Alcohol is of the most commonly abused substances, thus leading to significant medical and financial burdens. Pigs are an attractive model for studying alcohol abuse disorder (AUD) due to comparable alcohol consumption behavior and metabolism. This study investigates voluntary binge drinking behavior and provides a detailed analysis of associated motor…
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Large animal ischemic stroke models replicate human stroke pathophysiology

The high morbidity and mortality rate of ischemic stroke in humans has led to the development of numerous animal models that replicate human stroke to further understand the underlying pathophysiology and to explore potential therapeutic interventions. Although promising therapeutics have been identified using these animal models, with most undergoing significant…
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