Publications
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Histopathological analysis of cellular changes in the stroked brain provides critical information pertaining to inflammation, cell death, glial scarring, and other dynamic injury and recovery responses. However, commonly used manual approaches are hindered by limitations in speed, accuracy, bias, and the breadth of morphological information that can be obtained. Here, a semi-automated high-content imaging (HCI)…
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The objective of this study was to characterize brain anatomy and assess spatiotemporal gait parameters in two commonly utilized research pig breeds, Yucatan and Landrace, pre- and post-stroke using magnetic resonance imaging (MRI) and gait analysis. This study demonstrated Yucatan and Landrace pigs exhibit differences in gross brain anatomy and gait patterns pre-stroke. However, stroke…
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Alcohol is one of the most commonly abused intoxicants with 1 in 6 adults at risk for alcohol use disorder (AUD). As such, rodent AUD models are widely studied however, inherent anatomical and physiological differences between rodents and humans pose a number of limitations in studying the complex nature of human AUD. Comparatively, this review…
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The findings of this proof of concept study strongly suggest that administration of Tanshinone IIA loaded nanoparticles (Tan IIA-NP) in the acute phase post-stroke mitigates neural injury likely through limiting free radical formation, thus leading to less severe gait deficits in a translational pig ischemic stroke model. With stroke as one of the leading causes…
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Recently, it has been demonstrated that neurological diseases and associated pathologies correlate with changes in the gut microbiota. However, changes in the microbial community in stroke have not been well characterized. This study investigated the changes in the gut microbiota composition and diversity using a pig stroke model. These findings provide a basis for characterizing…
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Alcohol is of the most commonly abused substances, thus leading to significant medical and financial burdens. Pigs are an attractive model for studying alcohol abuse disorder (AUD) due to comparable alcohol consumption behavior and metabolism. This study investigates voluntary binge drinking behavior and provides a detailed analysis of associated motor function deficits in intoxicated pigs.…
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The acute stroke phase is a critical time frame used to evaluate stroke severity, therapeutic options, and prognosis while also serving as a major tool for the development of diagnostics. To further understand stroke pathophysiology and to enhance the development of treatments, our group developed a translational pig ischemic stroke model. In this study, the…
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Magnetic resonance imaging (MRI) is a clinically relevant non-invasive imaging tool commonly utilized to assess stroke progression in real time. This study investigated the utility of MRI as a predictive measure of clinical and functional outcomes when a stroke intervention is withheld or provided, in order to identify biomarkers for stroke functional outcome under these…
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The high morbidity and mortality rate of ischemic stroke in humans has led to the development of numerous animal models that replicate human stroke to further understand the underlying pathophysiology and to explore potential therapeutic interventions. Although promising therapeutics have been identified using these animal models, with most undergoing significant testing in rodent models, the…
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See our publication “Traumatic Brain Injury Results in Dynamic Brain Structure Changes Leading to Acute and Chronic Motor Function Deficits in a Pediatric Piglet Model” in the Journal of Neurotrauma.
Posted in: Publications