Erin Kaiser
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This study established a piglet brain tract model and conducts a comparative analysis of adult pig’s and piglet’s structural connectivity. These findings underscore the potential use of the piglet brain model in employing piglet model for developmental studies. Click on the following link for additional details: https://pubmed.ncbi.nlm.nih.gov/38588923/.
Posted in: Publications -
Pediatric traumatic brain injury (TBI) often induces significant disability in patients, including long-term motor deficits. Early detection of injury severity is key in determining a prognosis and creating appropriate intervention and rehabilitation plans. Diffusion tensor imaging (DTI) tractography enables three-dimensional reconstruction of specific white matter tracts throughout the brain in order to detect white matter…
Posted in: Publications -
A new stroke therapeutic based on collaborative research between the TNRR Laboratory and Aruna Bio will soon enter clinical trials. The U.S. Food and Drug Administration cleared the new drug, known as AB126, to enter a Phase 1b/2a clinical trial, which is expected to begin in the first half of 2024 . This first stage…
Posted in: News and Events -
Human mitochondrial DNA mutations are associated with common to rare mitochondrial disorders, which are multisystemic with complex clinical pathologies. The pathologies of these diseases are poorly understood and have no FDA-approved treatments leading to symptom management. Leigh syndrome (LS) is a pediatric mitochondrial disorder that affects the central nervous system during early development and causes…
Posted in: Publications -
This study aims to uncover important biomarkers and stroke recovery patterns based on physiological changes by developing two sparse CCA methods for multiple datasets. In analyzing the pig stroke data, we apply the proposed sparse CCA methods along with dimension reduction techniques, interpret the recovery patterns, and identify influential variables in recovery. Please click on…
Posted in: Publications -
Pediatric traumatic brain injury (TBI) is a leading cause of death and disability in children. Due to bidirectional communication between the brain and gut microbial population, introduction of key gut bacteria may mitigate critical TBI-induced secondary injury cascades, thus lessening neural damage and improving functional outcomes. The objective of this study was to determine the…
Posted in: Publications -
Impaired gut homeostasis is associated with stroke often presenting with leaky gut syndrome and increased gut, brain, and systemic inflammation that further exacerbates brain damage. We previously reported that intracisternal administration of Tanshinone IIA-loaded nanoparticles (Tan IIA-NPs) and transplantation of induced pluripotent stem cell-derived neural stem cells (iNSCs) led to enhanced neuroprotective and regenerative activity…
Posted in: Publications -
Functional connectivity (FC) measures statistical dependence between cortical brain regions. Studies of FC facilitate understanding of the brain’s function and architecture that underpin normal cognition, behavior, and changes associated with various factors (e.g. nutritional supplements) at a large scale. We aimed to identify modifications in FC patterns and targeted brain anatomies in piglets following perinatal…
Posted in: Publications -
In this study, we sought to further understand how nutritional supplements influence specific brain function and architecture as well as cognitive and behavioral performance. Specifically, we aimed to identify modifications in functional connectivity (FC) patterns and targeted brain anatomies in piglets following perinatal intake of different nutritional diets using a graph theory based approach where…
Posted in: Publications -
Human mitochondrial DNA mutations are associated with common to rare mitochondrial disorders, which are multisystemic with complex clinical pathologies. The pathologies of these diseases are poorly understood and have no FDA-approved treatments leading to symptom management. Leigh syndrome (LS) is a pediatric mitochondrial disorder that affects the central nervous system during early development and causes…
Posted in: Publications