Erin Kaiser
-
The ability of the brain to perform multiple complex tasks with fixed structures has yet to be fully elucidated. Structural connectivity (SC) and functional connectivity (FC) have been increasingly used to understand the structure and function of the brain respectively. However, a limited number of studies have explored the relationship between both entities especially in…
Posted in: Publications -
Human neural stem cells (hNSCs) possess significant therapeutic potential for the treatment of traumatic brain injury (TBI), a leading cause of global death and disability. Recent pre-clinical studies have shown that hNSCs reduce tissue damage and promote functional recovery through neuroprotective and regenerative signaling and cell replacement. Yet the overall efficacy of hNSCs for TBI…
Posted in: Publications -
University of Georgia researchers, including TNRR member Dr. Franklin West, have received a $3.7 million award to study the therapeutic efficacy of mesenchymal stem cells (MSCs) for the treatment of traumatic brain injury (TBI). Click this link to read the full story!
Posted in: News and Events -
In this study, we evaluated the effects of induced pluripotent stem cell-derived neural stem cell (iNSC) treatment on cellular, tissue, and functional recovery in a translational controlled cortical impact TBI piglet model. At 12-weeks post-transplantation, iNSCs showed long-term engraftment and differentiation into neurons, astrocytes, and oligodendrocytes. iNSC treatment enhanced endogenous neuroprotective and regenerative activities indicated…
Posted in: Publications -
Maternal nutrition during the perinatal stage is critical to offspring brain development. Egg yolks are a balanced and nutrient-dense food that is rich in bioactive components crucial to optimal neurodevelopment early in life. Egg consumption is often recommended to pregnant women to enhance both maternal and fetal health. The findings from this study support egg…
Posted in: Publications -
To better understand TBI’s impact on brain function and assess the efficacy of treatments, this study uses a novel temporal-spatial cross-group approach with a porcine model, integrating resting-state functional magnetic resonance imaging (rs-fMRI) for temporal and arterial spin labeling for spatial information. Read more about these results by clicking on the following link: https://pubmed.ncbi.nlm.nih.gov/39036426/.
Posted in: Publications -
This study established a piglet brain tract model and conducts a comparative analysis of adult pig’s and piglet’s structural connectivity. These findings underscore the potential use of the piglet brain model in employing piglet model for developmental studies. Click on the following link for additional details: https://pubmed.ncbi.nlm.nih.gov/38588923/.
Posted in: Publications -
Pediatric traumatic brain injury (TBI) often induces significant disability in patients, including long-term motor deficits. Early detection of injury severity is key in determining a prognosis and creating appropriate intervention and rehabilitation plans. Diffusion tensor imaging (DTI) tractography enables three-dimensional reconstruction of specific white matter tracts throughout the brain in order to detect white matter…
Posted in: Publications -
A new stroke therapeutic based on collaborative research between the TNRR Laboratory and Aruna Bio will soon enter clinical trials. The U.S. Food and Drug Administration cleared the new drug, known as AB126, to enter a Phase 1b/2a clinical trial, which is expected to begin in the first half of 2024 . This first stage…
Posted in: News and Events -
Human mitochondrial DNA mutations are associated with common to rare mitochondrial disorders, which are multisystemic with complex clinical pathologies. The pathologies of these diseases are poorly understood and have no FDA-approved treatments leading to symptom management. Leigh syndrome (LS) is a pediatric mitochondrial disorder that affects the central nervous system during early development and causes…
Posted in: Publications