Catalase activity in the brain is associated with recovery from brain injury in a piglet model of traumatic brain injury

This study examines the neuroprotective effects of the novel antioxidant alpha lipoic acid-based therapeutic, CMX-2043, on antioxidant enzymes in a preclinical TBI model via various drug administration routes. Specifically, intravenous administration enhanced liver catalase and brain SOD activity, while subcutaneous administration primarily elevated brain catalase activity. In addition, this study shows an association between increased brain catalase activity and decreased TBI brain lesioning, midline shift, and combined swelling and atrophy, thus emphasizing the role of antioxidant defenses in neuroprotection post-injury. Please click on the following link to read more: https://pubmed.ncbi.nlm.nih.gov/40563779/