Skip to Content

Alcohol induced brain and liver damage may be best modeled using pigs

Alcohol is one of the most commonly abused intoxicants with 1 in 6 adults at risk for alcohol use disorder (AUD). As such, rodent AUD models are widely studied however, inherent anatomical and physiological differences between rodents and humans pose a number of limitations in studying the complex nature of human AUD. Comparatively, this review describes how pigs and humans share anatomical similarities in the two major target organs of alcohol- the brain and liver. A porcine model of AUD possesses great translational potential that can significantly advance our current understanding of the complex development and continuance of AUD in humans.