Pig induced pluripotent stem cell-derived neural rosettes parallel human differentiation into sensory neural subtypes

The pig is the large animal model of choice for study of nerve regeneration and wound repair. Availability of porcine sensory neural cells would conceptually allow for analogous cell-based peripheral nerve regeneration in porcine injuries of similar severity and size to those found in humans. After recently reporting that porcine induced pluripotent stem cells differentiate into neural rosette (NR) structures similar to human NRs, here the TNRR Laboratory demonstrates porcine NR cells could differentiate into neural crest cells and other peripheral nervous system-relevant cell types.